Multiple insertions and tandem repeats of origin-minus simian virus 40 DNA in transformed rat and mouse cells
نویسندگان
چکیده
منابع مشابه
Origin of phenotypic variation in clones of simian virus 40-transformed mouse embryo cells.
This study explores the extent to which variations in the phenotype of normal cells determine the heterogeneity of their transformed counterparts. Transformed clones obtained after infection of a mixed population of mouse embryo cells by simian virus 40 were extremely variable in appearance and behavior. Clones obtained from primary cultures of mouse embryo cells were also found to have a quite...
متن کاملRearrangement of integrated viral DNA sequences in mouse cells transformed by simian virus 40.
The organization of viral DNA sequences in several cell lines derived from a primary colony of simian virus 40 (SV40)-transformed mouse cells was analyzed to examine the origin of the various distinctive patterns of SV40 sequence arrangement present in transformed cells. This analysis revealed a complex arrangement of viral sequences in the uncloned transformed cells but simplified arrangements...
متن کاملSuperinfection of simian virus 40-transformed permissive cells with simian virus 40.
Evidence that the resistance of simian virus (SV40)-transformed permissive cells to superinfection with SV40 is due to lack of virus uptake is presented. When virus uptake is enhanced, the events of infection proceed as in normal permissive cells, resulting in production of infectious virus.
متن کاملTumorigenicity of simian virus 40-transformed rat hepatocytes.
Simian virus 40 (SV40)-transformed F344 rat hepatocytes were transplanted into newborn and normal and irradiated adult syngeneic F344 hosts. Three independently isolated SV40-transformed hepatocyte cell lines were inoculated s.c. into newborn syngeneic animals. One cell line, SV40hpl, produced tumors in two of 12 animals. Fixed tissue sections indicated that the tumors were relatively undiffere...
متن کاملTumorigenicity of simian virus 40-transformed human cells and mouse--human hybrids in nude mice.
Four different human cell lines transformed by simian virus 40 (SV40) were tested for their tumorigenicity in athymic nude mice. Two of these lines, W18Va2 and GM52VA, were found to be tumorigenic when inoculated at a concentration of 1 x 10(7) cells per mouse. The other two cell lines, LN-SV and GM54VA, were found to induce very small tumors only after the injection of approximately 1 x 10(8) ...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1988
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.62.5.1520-1523.1988